Hendri Nofa, Yusrizal Chan, Masrul Basyar, Oea Khairsyaf
Departemen Pulmonologi dan Ilmu Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang
Background: Azithromycin is a macrolide, that have antibiotic anti inflammation property that might decrease progresivity of chronic obstructive pulmonary disease (COPD). CAT is a simple questionnaire, useful and sensitive for the assesing effect of COPD toward health status. The aim of this study is to evaluate effect of 8 weeks azithromycin toward CAT scores.
Methods: Clinical study enrolled 25 stable COPD outpatients Dr. M. Djamil hospital in Padang between September 2013 and April 2014 who gave azithromycin 250 mg three times a weeks for 8 weeks. CAT scores was evaluated before and after treatment. Data of CAT before and after treatment was analyzed with t test.
Results: The mean age of the study is 69±6.9 years, degree of COPD predominantly was severe (64%) and CAT score was moderate (96%). Azithromycin decreased CAT score from 14.52 to 12.48 (p=0.019). CAT variable that significantly affected were cough, sputum, and chest tighness.
Conclusion: Azithromycin 250 mg for eight weeks affected decrease CAT scores. It influences cough, sputum production and tighness of chest significantly. (J Respir Indo. 2015; 35: 46-50)
Keywords: COPD, inflammation, macrolide, CAT scores.