Category archives for Biomolecular

Profile of Serum C-Reactive Protein Levels in Confirmed Tuberculosis HIV Coinfection

Budi Yanti, Laksmi Wulandari Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Syiah Kuala, RSUD Dr. Zainoel Abidin, Banda Aceh Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background: Diagnosis of tuberculosis (TB) in HIV-infected patients is often difficult due to several reasons: frequently negative sputum smear; atypical radiographical […]

Tuberculosis with Eosinophilic Mass and Dark Brown Particles

Delyuzar1, M. Najib Dahlan Lubis1, Zainuddin Amir2, Lia Kusumawati3 1Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Sumatera Utara, Medan 2Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sumatera Utara, Medan 3Departemen Mikrobiologi, Fakultas Kedokteran Universitas Sumatera Utara, Medan Abstract Background: Sputum smear examination and X-ray images have been used to identify pulmonary tuberculosis patients. For extrapulmonary […]

The Relationship of Smoking Degree with Sputum IFN-γ Levels in Smear-Positive Pulmonary TB Patients

Irmi Syafa’ah, Winariani K Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background: Tuberculosis and smoking aretwo major health problems in the world. Indonesia ranks as the second highest country in term of TB cases and ranked 4th as the highest cigarettes consumers in the world. Exposure to smoking […]

Expression of Protein Telomerase on Paraffin Block Preparations of Non-Small Cell Lung Cancer

Heidy Agustin1, Elisna Syahruddin1, Faisal Yunus1, Endarjo S2 1Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta 2Departemen Patologi Anatomi, RSUP Persahabatan, Jakarta Abstract Background: Lung cancer is a leading cause of death from cancer group. Prooncogenes and tumor suppressor genes role are separately known as k-ras, p53 and myc. Other factors […]

Comparison of Gefitinib Response in NSCLC Patients with EGFR Mutation Exon 19 and Exon 21

Titin Sholihah Agustina, Laksmi Wulandari Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background:. Lung cancer categorized as small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC). One major factor of growth of the cancer cell is the mutation of gen epidermal growth factor receptor (EGFR). […]

Levels of HDAC2 and SGRQ-C in C and D Grup COPD Patients with Inhaled ICS/LABA and History of Smoking

Triwahju Astuti, Ungky Agus Setyawan, Sri Handayani Rahayu Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Brawijaya, Malang Abstract Background: In chronic obstructive pulmonary disease (COPD,) especially in smoker patients, there is a reduction in histone deacetylase-2 (HDAC2) activity and expression which is caused by oxidative stress. It’s linked with corticosteroids resistance. GOLD recommendation therapy […]

Effect of Pravastatin on Serum Level of IL-6, Procalcitonin, and Duration to Clinical Improvement in Pneumonia Patients

Jan Yanto Lydwines Purba,1,2 Reviono,1 Suradi,1 Harsini,1 Jatu Aphridasari1 1. Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta 2. Program Pasca Sarjana Minat Kedokteran Keluarga Biomedik Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta Abstract Background: Pneumonia is an inflammatory disease caused by pathogen microbes. Inflamation reaction aimed […]

Relation Between Interleukin-17 Level in Sputum Induction with FEF25-75% in Asthma

Salva Badjarad, Daniel Maranatha Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background: Asthma is a chronic obstructive airway disease markedly by inflammation and airway hyperresponsiveness. Astma is one of causes of morbidity and mortality in Indonesia. Asthma has different manifestations of inflammatory patterns such as Th1, Th2 and […]

Correlation Between Pneumocystis jirovecii Pneumonia and Elevated Serum Levels of Lactate Dehydrogenase in HIV

Elizabeth Vania, Tutik Kusmiati Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background: Pneumocystis pneumonia (PCP) is a major cause of morbidity and mortality in immunocompromised individuals caused by Pneumocystis jirovecii. The diagnosis of PCP is difficult since causative organism can not be cultured, and the diagnosis is based […]

Factors Affecting Sputum Conversion in New Cases of Pulmonary Tuberculosis Patients New Cases with Diabetes Mellitus

Iceu Dimas Kulsum,1 Erlina Burhan,1 Rochismandoko2 1Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta 2Departemen Ilmu Penyakit Dalam, RSUP Persahabatan, Jakarta Abstract Background: The prevalence of diabetes mellitus (DM) continues to increase in developing countries where TB is endemic. Immunocompromised due to DM increases the risk of TB infection and delayed […]

Effect of Resveratrol to The Plasma Level of Interleukin-8, MMP-9 and CAT Score of Acute Exacerbation COPD Patient

Evata Putri,1,2 Suradi,1 Diffah,1 Harsini1 1Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta 2Program Pasca Sarjana Minat Kedokteran Keluarga Biomedik Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta Abstract Background: Chronic obstructive pulmonary disease (COPD) is pulmonary disease which is marked with not fully reversible of respiratory obstructive […]

Comparison of Cardiopulmonary Endurance, Lung Function Test and Salivary Superoxide Dismutase (SOD) Levels Among Smokers and Non Smokers

Decky Gunawan,1 Rizna Tyrani Rumanti,2 Cindra Paskaria3 1Bagian Fisiologi Universitas Kristen Maranatha Bandung 2Bagian Anatomi Universitas Kristen Maranatha Bandung 3Bagian Ilmu Kesehatan Masyarakat Universitas Kristen Maranatha Bandung Abstract Background: Smoking is one of human lifestyle which difficult to abandon and can cause health problems. Eighty five percent of households in Indonesia exposed to smoke with […]

Efficacy Varenicline in Smoking Cessation Programme A Randomized, Single-Blind, Placebo Controlled Trial

Mirsyam Ratri Wiratmoko,1,2 Agus Dwi Susanto,1,3 Faisal Yunus,1 Tribowo Tuahta Ginting3,4 1Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta 2Departemen Ilmu Penyakit Dalam Program Studi Pendidikan Dokter Fakultas Kedokteran dan Kesehatan Universitas Muhammadiyah Jakarta 3Klinik Berhenti Merokok, RSUP Persahabatan 4Satuan Medis Fungsional Ilmu Kesehatan Jiwa, RSUP Persahabatan, Jakarta Abstract Background: Smoking […]

Accuracy of Urine LAM TB Antigen Test as an Alternative Method of Pulmonary Tuberculosis Diagnosis; Evidence-based Case Report

Hafizh A Boenjamin,1 Ikrar Syahmar,1 Joseph Prasetyo,1Nadim Marchian,1 Theresia Rini,1 Jamal Zaini2 1Program Pendidikan Dokter Fakultas Kedokteran Universitas Indonesia 2Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta Abstract Tuberculosis (TB) cases are found in many developing countries, such as Indonesia. The diagnosis of TB still depends on microscopic examination of sputum […]

The Effect of zinc for 5 Day on endothelin-1, Tumor Necrosis Factor-Α and Clinical Improvement in Patients with Pneumonia

Agung Dewantara, Suradi, Reviono, Ana Rima, Harsini, Jatu Aphridasari Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sebelas Maret Surakarta, RSUD dr. Moewardi, Surakarta Program Pasca Sarjana Minat Kedokteran Keluarga Biomedik Fakultas Kedokteran Universitas Sebelas Maret Surakarta, RSUD dr. Moewardi, Surakarta Abstract Background: Many attempts to find out the prognostic of pneumonia, one off them […]

Plasma suPAR Level and Clinical Characteristics as Predicting Factors for the Result of Mycobacterium tuberculosis Culture in Suspected MDR-TB Patients

Triwahju Astuti,1 Tri Yudani Mardining Raras,2 Dian Nugrahenny,3 Rahadi Widodo1 1Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Brawijaya, Malang 2Laboratorium Biomedik, Fakultas Kedokteran Universitas Brawijaya, Malang 3Laboratorium Farmakologi, Fakultas Kedokteran Universitas Brawijaya, Malang Abstract Background: In suspected MDR-TB patients with smear AFB remains positive after treatment, the results of mycobacterial culture are not always […]

Ultraviolet Rays Exposure on Levels of Interleukin 17 in Controlled Partial Asthma Patients

Abdulloh Najich, Arief Bakhtiar, Muhammad Amin Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya Abstract Background: Asthma is a serious public health problem in the world, its prevalence is increasing in areas away from the equator, the effect of exposure to ultraviolet (UV) from the sun as protection of allergies. […]

Proportion and Profile of Epidermal Growth Factor Receptor Mutation in Young Lung Adenocarcinoma

Mia Elhidsi, Sita Laksmi Andarini, Achmad Hudoyo Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta Abstract Background: Epidermal growth factor receptor mutation is associated with Lung Adenocarcinoma carcinogenesis particularly in young patients which don’t have long exposure to smoke as carcinogen. This study investigates the profile of epidermal growth factor receptor […]

The Effect of Amniotic Membrane Mesenchymal Stem Cell Conditioned Media (MSC-CM) on Cigarette Smoke Induced Lung Damage (an experimental study in mice)

Handi Priambodo,1 Suradi,1 Reviono,1 Yusup S Sutanto,1 Ana Rima,1 Harsini,1 Yuyun Rindiastuti,2 Abdurahman Laqif,3 Indah Julianto2 1Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta 2Departemen Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta 3Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, […]

The Role of T-Helper 17 Cells in Asthma

Arry Setyowati, Jatu Aphridasari Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta Abstract Asthma is a worldwide health problem with increasing prevalence in several countries. Inflammatory disorders of chronic breath channel on asthma involves a lot of cells and cellular elements. Inflammatory tract in asthma is triggered by response […]

The Role of Xanthine in Pulmonary Obstructive Disease

Budi Yanti,1 Menaldi Rasmin2 1SMF Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Syiah Kuala, RSUD Dr. Zainoel Abidin, Banda Aceh 2 Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta Abstract Theophylline has been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD) for over 60 years and remains […]

Cumulative Exposure of Dust Stone Serum Levels to Interleukin-13 and Lung Function of Breaking Stones Workers

Ida Ayu Jasminarti, Winariani Departemen Pulmonologi dan Kedokteran Respirasi Universitas Airlangga Surabaya Abstract Background: Stone mining is a profession with high risks to occupational lung disease due to silica inhalation in working environment causing silicosis. Silicosis is a fibrosing disease of the lungs caused by the inhalation, retention, and pulmonary reaction to crystalline silica. Particles […]

Effect of Omega 3 Fatty Acids to Procalcitonin Concentration and Survival of Clinical Community Pneumonia Patient

Susanto Eko Prasetyo,1 Reviono,2 Suradi2 1 Mahasiswa Program Pendidikan Dokter Spesialis I Pulmonologi dan Kedokteran Respirasi, Universitas Sebelas Maret, Surakarta 2 Staff Pengajar Program Pendidikan Dokter Spesialis I Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, Surakarta Abstract Background: Diagnosis of pneumonia will be fast if using biomarkers such as procalcitonin. The main objective […]

Effect of Inhaled Furosemide on Plasma Levels of Interleukin-8 and CAT Scores of Acute Exacerbations COPD Patients

Widayanto,1 Suradi,2 Ana Rima Setijadi2 1 Mahasiswa Program Studi Kedokteran Keluarga, Program Pascasarjana, Universitas Sebelas Maret, Surakarta 2 Staf Pengajar Program Pendidikan Dokter Spesialis I Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, Surakarta Abstract Background: Interleukin-8 is a proinflammatory cytokines are elevated in acute exacerbation of COPD. CAT scores will increase with worsening […]