Anik Sukmawati, Muhammad Amin
Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Airlangga, Surabaya
Background: Cigarette smoking causes small airway obstruction (SAO) and is the harbinger of developing chronic obstructive pulmonary disease (COPD). The reduction in FEF25-75% associated with chronic cigarette smoking can be explained by loss of lung elastic recoil pressure which reduces the force driving air out of the lung. Therefore early detection of pulmonary function tests will prevent the risk of airway disease. The aim of the present study is to analyze pulmonary function changes, FEF25-75% in smoking and to compare them with
healthy non smokers.
Methods: In this study 96 healthy male and female subjects, their age ranging from 30-70 years, 48 smokers and 48 nonsmokers were assessed for their pulmonary function tests by using a spirometer.
Results: Study showed that impact of cigarette smoking on pulmonary function in smokers had a significantly greater percentage decline in the FEF25-75%, ratio than non-smokers (p<0,05), they suggested that smokers develop changes in pulmonary function indicating early peripheral airway narrowing. There were significant correlation between smoking duration and rate of values FEF25-75%. We found a dose-response relation between smoking and FEF25-75%. Duration and amount of smoking were associated reduction in FEF25-75%.
Conclusion: Smokers had a significantly greater percentage decline in the FEF25-75% than non-smokers. There were significant correlation between smoking duration and rate of values FEF25-75%. The deterioration of lung functions related to the number of cigarettes smoked per day in smokers. (J Respir Indo. 2016; 36: 167-74)
Keywords: FEF25-75%, small airway obstruction, smoking, non smoking, spirometer