Suwarti SA, Chan Y, Zainoeddin ZY, Taufik, Khairsyaf O
J Respir Indo. 2012;32:233-9
Background: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with airflow limitation that is not fully reversible. Tobacco smoke and air pollution can cause oxidative stress which contribute in cell and tissue damage. N-Acetylcysteine is an antioxidant that used as additional drug in COPD treatment. It can improve both lung function and quality life in COPD patients and can reduce exacerbation.
Methods: This is a clinical trial study on two open independent groups consist of outpatients with stable COPD. The first group with N-Acetyl cysteine, aminophylline and salbutamol and the control group with aminophylline and salbutamol. For each group we performed lung function test and six minutes walk test both at baseline and after two month received N-Acetyl cysteine.
Results: We found 49 eligible patients and all of them were man. The group which had gotten N-Acetyl cysteine for two months showed improvement in FEV , FVC and six minutes walk test.
Conclusion: N-Acetyl cysteine has role in lung function improvement and six minutes walk test improvement.
Keywords: N-Acetyl cysteine, COPD, FEV (force expiration volume first second), FVC (force vital capacity), six minute walk test.