Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad

Dani Rosdiana, Dewi Anggraini, Indra Yovi, Marlina Tasril

Abstract


Backgrounds: Diabetes melitus (DM) increase risk of reactivation of tuberculosis included multiresistent drug tuberculosis (MDR-TB). This situation treated Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB managed MDR-TB patients. We should evaluated the patients especially DM patients.
Methods: This is a cross sectional retrospective research. The aim of this research are evaluating and analyzing the characteristic of patients, time of conversion of smear or culture, side effect of drugs and outcome of all patients from 2014 – 2017. We analyzed the difference of the DM and Non DM groups.
Results: We got 140 MDR-TB patients, but only 113 patients had complete medical records. There was 26,5% MDR-TB patients with DM, the most frequency of side effects are nausea and vomitus (100%). We found in MDR-TB DM group that 16,7% got severe side effects, 40% had smear or culture conversion on 2nd month, and six patient (20%) cured.
Conclusions: There were no differences of side effects, smear conversion and outcome between DM and Non DM group. The age more than 50 years old has a significant differences between DM and Non DM group.

Keywords


MDR-TB, Diabetes Melitus, side effects, conversion, outcome

References


Global Tuberculosis Report 2016. http://apps.who.int/medicinedocs/en/d/Js23098en/

Reviono, Kusnanto P, Eko V, Pakiding H, Nurwidiasih D. Multidrug Resistant Tuberculosis (MDR-TB): Tinjauan Epidemiologi dan Faktor Risiko Efek Samping Obat Anti Tuberkulosis. MKB.2014:46(14):189-196.

Murray JF, Schraufnagel DE, Hopewell PC. Treatment of Tuberculosis A Historical Perspective. Ann Am Thorac Soc. 2015; 12 (12): 1749–1759.

Saleri N, Dembe´le´ SM, Villani P, Carvalho ANC, Cusato M, Bonkoungou V. et.all. Systemic Exposure to Rifampicin in Patients With Tuberculosis and Advanced HIV Disease During Highly Active Antiretroviral Therapy in Burkina Faso. J Antimicrob Chemother 2012; 67: 469 –472.

Keshavjee S, and Farmer PE. Tuberculosis, Drug Resistance, and the History of Modern Medicine. N Engl J Med. 2012;367:931-6. DOI: 10.1056/NEJMra1205429

World Health Organization. Collaborative framework for care and control of Tuberculosis and diabetes. 2011

Rosdiana D. Multidrug Resistant Tuberculosis with Diabetes Mellitus as a Comorbidity: a case report. J Kesehat Melayu. 2017;1(1):45-51.

Bashar M, Alcabes P, Rom WN, Condos R. Increase Incidence Multidrug Resistance Tuberculosis in Diabetic Patient on the Bellevue Chest Service 1987 to 1997. Chest. 2001;120:1514-9.

Suradi PW, Surjanto E. Hubungan Antara Diabetes Mellitus dengan Multidrug Resistant pada Penderita Tuberkulosis Di Surakarta. J Respir Indo. 2004;25:24-8.

Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff TH et al. The Effect of Type 2 Diabetes Mellitus on the Presentation and Treatment Response of Pulmonary Tuberculosis. Clinical Infectious Disease. 2007;45:428-35

Zhang Y, Yew WW. Mechanisms of Drug Resistance in Mycobacterium Tuberculosis. Int J Tuberc Lung Dis 2009;13(11):1320–30.

Rumende CM. Risk Factors for Multidrug-resistant Tuberculosis. Acta Med Indones - Indones J Intern Med. 2018: 1-2.

American Diabetes Association. Criteria for Type 2 Diabetes Diagnosis. Diabetes Care Journal. 2015; 38 (1): S8–S16

Wijayanto A, Burhan E, Nawas A, Rochsismandoko. Faktor Terjadinya Tuberkulosis Paru pada Pasien Diabetes Mellitus Tipe 2. J Respir Indo. 2015 Jan 1; 35 (1): 1-11

Kementerian Kesehatan RI. Petunjuk Teknis Pengobatan Pasien TB Resistan Obat dengan Paduan Standar Jangka Pendek di Fasyankes TB Resistan Obat. Kementerian Kesehatan RI, 2017.

El Din MAT, El Maraghy AA, Hay A. Adverse Reactions Among Patients Being Treated for Multi-Drug Resistant Tuberculosis at Abbassia Chest Hospital. Egyptian Journal of Chest Diseases and Tuberculosis. 2015; 64. 939-52.

Holland DP, Sanders GD, Hamilton CD, Stout JE. Strategies for Treating Latent Multiple-Drug Resistant Tuberculosis: A Decision Analysis. PLoS ONE. 2012 Jan; 7(1): 1-2

Liang L, Wu Q, Gao L, Hao Y, Liu C, Xie Y, Sun H et al. Factors Contributing to the High Prevalence of Multidrug-Resistant Tuberculosis: a study from China. Thorax. 2012;67:632-8. doi:10.1136/thoraxjnl-2011-200018.




DOI: https://doi.org/10.36497/jri.v40i3.119

Refbacks

  • There are currently no refbacks.





Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845
Email: editor@jurnalrespirologi.org


An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International License

Statcounter