Pleurodesis in Malignant Pleural Effusion

· Article Review, Thoracic Oncology

Dicky Soehardiman, Wiendo Syah Putra Yahya, Fathiyah Isbaniyah
Departemen Pulmonologi dan Ilmu Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia, RS Persahabatan, Jakarta


Malignant pleural effusion (MPE) are commonly found in intrathoracic and extrathoracic malignancies. The diagnosis of malignant pleural effusions is established by thoracocentesis with a cytological analysis of the pleural fluid or needle biopsy of the pleura and thoracoscopy with pleural biopsy. Pleurodesis has been recommended by ATS and BTS as palliative therapy in patients with recurrent accumulation of pleural fluid, had symptoms of shortness of breath and prognosis of more than 1 month. Tetracycline, povidone iodine, bleomycin and talc were the sclerosing agents of choice. Talc as the sclerosant of choice and thoracoscopic talc poudrage as the preferred technique that should be considered for all patients with good performance status. Acute respiratory distress syndrome (ARDS) was serious side effects reported after pleurodesis with talc. (J Respir Indo. 2014; 34: 218-28)
Keywords: malignant pleural effusion, pleurodesis, sclerosing agents, talc

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