Proportion and Profile of Epidermal Growth Factor Receptor Mutation in Young Lung Adenocarcinoma

· Biomolecular, Thoracic Oncology

Mia Elhidsi, Sita Laksmi Andarini, Achmad Hudoyo
Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta

Background: Epidermal growth factor receptor mutation is associated with Lung Adenocarcinoma carcinogenesis particularly in young patients which don’t have long exposure to smoke as carcinogen. This study investigates the profile of epidermal growth factor receptor mutation in young lung Adenocarcinoma.
Methods: Cross sectional study in lung Adenocarcinoma <45 years old compare with olders. Data were taken from medical record Persahabatan hospital Jakarta 2012-2013.
Results: A total 218 lung Adenocarcinoma consists of 65 young patients and 153 olders. Young lung Adenocarcinomas are female (58,3%), nonsmokers (66,7%), advanced stage (98,5%), performance status WHO ≤2, extrathoracic metastatics (43,1%). EGFR mutation in youngers are higher than olders (70,8%vs51,6%; p=0,007). Mutation in young patients consists of 36,9% exon 19 deletion; 30,8% exon 21 L858R mutation; 3,1% exon 21 L861Q mutation and 29,2% wild type
Conclusion: Proportion of EGFR mutation especially in exon 19 is high in young lung Adenocarcinoma. This allows more effective targeted therapy. (J Respir Indo. 2016; 36: 244-8)

Keywords: EGFR mutation, lung Adenocarcinoma, young

Click here for full paper (PDF)