Relationship between Procalcitonin Concentration with Etiology of Community Acquired Pneumonia Patients

· Critical Care, Lung Infection

Desi Susyanti, Taufik, Oea Khairsyaf, Irvan Medison

Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, RS Dr. M. Djamil Padang

Background: Antibiotic overuse for community acquired pneumoia (CAP) is associated with drug resistance and hospital-acquired infection. It is important to distinguish bacterial pneumonia from non-bacterial pneumonia to less antibiotic overuse. Procalcitonin (PCT) test could identify bacterial pneumonia faster than other conservative laboratory test.
Methods: Cross sectional study with subjects patients with CAP that hospitalized in pulmonary ward at Dr. M. Djamil Padang Hospital from December 2012 to February 2013. PCT level test and poly chain reaction (PCR) test were performed to confirmed the etiology. Analyzed the association between PCT levels and etiology of pneumonia based on PCR test and calculated specitivity, sensitivity, and ROC curve.
Results: From 50 patients with CAP, 44 (88%) of them had a final diagnosis of bacterial pneumonia. PCT’s level in bacterial pneumonia higher than in non-bacterial pneumonia (mean 0.85018 ± 0.490876 vs 0.11033 ± 0.090965). Rank Spearman test were performed using correlation coefficient r = 0.563 ; nilai p <0,00001 is considering as significant correlation. With cut off point >0,5 ng/ml sensitivity 93,18% and specificity 100% and ROC analysis demonstrated an area under curve (AUC) of 0.966 (95% CI, 0.918 to 1.000).
Conclusion: PCT’s level could distinguished bacterial pneumonia from non bacterial pneumonia with cut off point of 0,5 ng/mL. (J Respir Indo. 2014; 34:71-6)
Key words: procalcitonin, etiology, community acquired pneumonia.

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