Arry Setyowati, Jatu Aphridasari
Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta
Asthma is a worldwide health problem with increasing prevalence in several countries. Inflammatory disorders of chronic breath channel on asthma involves a lot of cells and cellular elements. Inflammatory tract in asthma is triggered by response of lymphocytes T helper cell (Th)-2. Three sub-sets of Th cells that inhibit the function of Th -1 and Th-2 have been found, that is Th-17. T-helper 17 cells which produces cells of various pro-inflammatory cytokine, TNF-α, IL-1β, IL-6, and interleukins is a relatively new IL-17A, IL-17B, IL-17C, IL-17D,IL-17E (also called IL-25), IL-17F, IL-9, IL-15 and IL-26. Th-17 producing cells of IL-17 and other cytokines that act on the breath channel bronchoconstriction. Interleukin-17 played an important role in the immune response and inflammation by regulating the expression of various inflammatory mediators including cytokines, adhesion molecules, kemokin, and growth factors. Heavy breathing is correlated with hypersensitivity channels of expression Th-17. A variety of molecules that regulate cell differentiation or stabilization of Th-17 can be a target for reducing the expression of IL-17 i.e. blockade activity IL-5, IL-17 production modulation, an inhibitor of kinase inhibitors, transcription factors, an inhibitor of phosphodiesterase 4 (PDE4) enzyme inhibitor, statin, VEGF, steroids, resolvin E1, and vitamin D. Investigation and regulation of cell differentiation, Th-17 offers new ways for asthma therapy. (J Respir Indo. 2016; 36: 257-66)
Keywords: T helper 17 cells, asthma.