Correlation Between Neutrofil-Limphocyte Ratio Before Chemoteraphy and Objective Response Platinum based Chemoteraphy on Lung Cancer Patient

Nikson Eduard Faot, Isnu Pradjoko

Abstract


Background: Lung cancer is the leading cause of death from cancer. One type of cancer is non-small cell lung cancer (NSCLC). The body fights against cancer cells by immune surveillance mechanisms involving the role of neutrophils and lymphocytes. Chemotherapy is a modality that is usually used as a therapy in patients’ NSCLC. To assess chemotherapy’s prognostic, research needs to be done to find the relationship between the neutrophil-lymphocytes ratio before chemotherapy with objective response after chemotherapy in patients with NSCLC
Methods: This study was an observational study of retrospective cohort analytics which samples are secondary data from medical records of NSCLC patients in RSUD Dr. Soetomo who received chemotherapy by linking the neutrophils-lymphocytes ratio before chemotherapy with objective response after chemotherapy based on RECIST’s criteria and analyzed by spearman correlation test method and RNL cut off value with ROC curve and kappa test
Results: Sixty-four subjects were analyzed in this study, the relationship of neutrophil-lymphocyte ratio with chemotherapy objective response after 2 cycles with P=0.354 (<0.004), rs=0.34 and cut off RNL value to progressive disease 3,75 with sensitivity 76% and Specificity 59%. There was no relationship of neutrophil-lymphocyte ratio with objective chemotherapy response after 4 cycles P=0.738.
Conclusion: The neutrophil-lymphocyte ratio with objective response after 2 cycles of chemotherapy had a significant association. The RNL cut point value was obtained 0.37 against progressive disease with a weak agreement. (J Respir Indo. 2017; 37(4): 293-8)

Keywords


lung cancer, neutrophil-lymphocyte ratio, objective response

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References


Steward BW. World Cancer Report. Report. International Agency For Research, WHO: 2014.

Jususf A, Syahruddin, Wibawanto A, dkk. Kanker Paru (kanker paru jenis karsinoma bukan sel kecil). Pedoman Diagnosis Dan Penatalaksanaan Di Indonesia. Jakarta: PDPI; 2011. p.1-35.

Cancer Facts & Figures 2016. In American Cancer Society; 2016.

Murray. Bronchogenic carcinoma. In: Mason RJ ed. Murray and Nadel's Textbook Of Respiratory Medicine; 4th edition. Philadelphia: Elsevier Saunders; 2005. p.1357-82

Li M, Xiao WX, Hai YM, et al. Clinical evaluation of tumor markers for diagnosis in patients with non-small cell lung cancer in China. Asian Pacific Journal Of Cancer Prevention. 2015;16(12):4891-4.

Tavares BM, Candido EF. Systemic leukocyte alterations in cancer and their relation to prognosis. The Open Cancer Journal. 2008;(2):53-8.

Callaghan DS, Donnel D, Connel F, et al. The role of inflammation in the pathogenesis of non-small cell lung cancer. Journal of Thoracic Oncology. 2010;(5):2024-36.

Sarraf KM, Belcher, Raevsky F et al. Neutrophil/Lymphocyte Ratio and its association with survival aftercomplete resection in non-small cell lung cancer. Journal Of Thoracic Cardiovascular Surgery. 2009;137(2):425-8.

Kumar BS, Mandal A, Deoghuria D, et al. Clinico pathological profile of lung cancer in tertiary medical center in India: Analysis of 266 cases. Journal of Dent Oral hyg 2011;3:30-3.

Kreuzer M,Boffetta P, Whitley E et al. Gender differences in lung cancer risk by smoking: a multicentre case-control study in Germany and Italy. British Journal of Cancer.2000;82(1): 227–233

Rawat J, Sindhwani, Gaur, et al. Clinico-pathological profile of lung cancer in Uttarakhand, Lung India. 2009; 26:74-9.

Yao Y, Yuan D, Liu H. Pretreatment neutrofil to lymphocyte ratio is associated with respons to therapy and prognosis of advanced non- small cell lung cancer patient treated with first-line platinum base. Cancer Immunol Immunother. 2013;62:471–9.

Berardi B, Rinald S, Santoni M, et al. Prognostic Model To Predict Survival In Patient With Advanced Non Small Cell Lung Cancer Treated With First-Line Chemotherapy Or Targeted Therapy. Oncotarget. 2015;7(18):26917-24.

Yin Y, Wang J, Gu Lan Et Al. prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta analisis. Clinics. 2015;70:524-30.

Zhang X, Zou Z, Fan L et al. Neutrophil to Lymphocyte Ratio (NLR) in Peripheral Blood: A Novel and Simple Prognostic Predictor of Non-small Cell Lung Cancer (NSCLC). Journal Hemato.




DOI: https://doi.org/10.36497/jri.v37i4.84

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