Correlation Between Pleural Fluid GenXpert® and Histopathology Finding of Pleural Biopsy in Tuberculous Pleural Effusion

Authors

  • Sheilla Matheos Universitas Airlangga
  • Isnin Anang Marhana Universitas Airlangga
  • Anny Setijo Rahaju Universitas Airlangga

DOI:

https://doi.org/10.36497/jri.v38i1.133

Keywords:

pleural effusion, TB pleural effusion, GenXpert®, pleural biopsy

Abstract

Backgrounds: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB, but a definite diagnosis is still a challenge. Pleural biopsy has historically been the gold standard procedure for the diagnosis of pleural tuberculosis. GenXpert® is a computerize test based in nucleic acid amplification tahat automatically detect MTB and rifampicin resistance. This study aimed to prove the correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. Methods: This study used an observational analytic design with a cross-sectional design conducted in Dr. Soetomo Hospital, Surabaya in March-June 2017. Statistic analysis was using chi square test and contingensi coofisient. The pleural GenXpert® was tested in 23 patients with pleural effusion and their biopsy speciments underwent histopathological analysis. Results: Histopathological findings of pleural biopsy was positive in 4 subjects and pleural fluid GenXpert® resulted positive in 6 subjects. There was significant correlation between pleural fluid GenXpert® and histopathological findings of specimen pleural biopsy in patients with pleural tuberculosis (P=0.040) with moderate strenght (P=0.014). Sensitivity and specificity of pleural fluid GenXpert® were 75.0% dan 84.2% respectively. Conclusions: There was significant correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. (J Respir Indo 2018; 38(1): 1-6)

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Author Biographies

  • Sheilla Matheos, Universitas Airlangga
    Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran
  • Isnin Anang Marhana, Universitas Airlangga
    Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran
  • Anny Setijo Rahaju, Universitas Airlangga
    Departemen Patologi Anatomi Fakultas Kedokteran

References

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Christopher D, Schumacher S. Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis. Eur Respir J. 2013;42:1427–9.

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Published

2020-01-06

Issue

Section

Original Article

How to Cite

Correlation Between Pleural Fluid GenXpert® and Histopathology Finding of Pleural Biopsy in Tuberculous Pleural Effusion. (2020). Jurnal Respirologi Indonesia, 38(1), 1-6. https://doi.org/10.36497/jri.v38i1.133

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