The Effect of Ophiocephalus Striatus Extract on suPAR, Neutrophil Levels and Lung Diffusion Capacity (DLCO) in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients with Muscle Wasting

Sasongko Adhi Nugroho, Teguh Rahayu Sartono, Susanthy Djajalaksana, Harun Al Rasyid


Background: Muscle wasting is one of the extrapulmonary manifestation which influence quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. It caused by imbalance of protein metabolism in skeletal muscle. This study aimed to evaluate the effect of Ophiocephalus striatus extract on neutrophil count, soluble urokinase-type plasminogen activator (suPAR) level, diffusion capacity of lung for carbon monoxide (DLCO) and quality of life in stable COPD patients with muscle wasting.
Methods: Clinical pre and post quasi experimental study was conducted to 32 stable muscle-wasted COPD patients from Pulmonary Outpatient Clinic Saiful Anwar Hospital Malang, determined by The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016, Bioelectrical impedance analysis (BIA) dengan fat-free mass (FFM) <14.6 kg/m and Body Mass Index (BMI) <18.5 kg/m2, measurements of suPAR levels by enzyme-linked immunosorbent assay (ELISA), neutrophil count with blood analysis, DLCO with bodyplethysmography and CAT score as health-parameters COPD quality of life were performed before and after intervention of 3000 mg Ophiocephalus striatus extract for 12 weeks.
Results: There were significant decreased of CAT score (18.34±8.031 to 10.81±7.66, p=0.000), unsignificant decreased of suPAR (3.93±2.04 pg/mL to 3.77±1.67 pg/mL, p=0.67), unsignificant decreased of neutrophil (61.74±11.54% to 60.86±10.46%, p=0.619), unsignificant increased of DLCO (53.73±24,56% to 56.06±25,93% p = 0.369). There were weak negative correlations between suPAR to CAT score (r=0.44; p=0.813) and DLCO (r=-0.170; p=0.352), weak positive correlation between suPAR to neutrophil (r=0.167; p=0.370).
Conclusion: Twelve weeks supplementation of Ophiocephalus striatus extract in stable COPD patients with muscle wasting unsignificantly decrease suPAR and neutrophil levels and increase DLCO, but significant on CAT scores. No correlation between changes in suPAR, neutrofil, DLCO to CAT scores. (J Respir Indo 2019; 39(2): 79-87)


Ophiocephalus striatus extract, COPD, muscle wasting, suPAR, Neutrophil

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