The Effect of Ophiocephalus Striatus Extract on suPAR, Neutrophil Levels and Lung Diffusion Capacity (DLCO) in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients with Muscle Wasting

Sasongko Adhi Nugroho, Teguh Rahayu Sartono, Susanthy Djajalaksana, Harun Al Rasyid

Abstract


Background: Muscle wasting is one of the extrapulmonary manifestation which influence quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. It caused by imbalance of protein metabolism in skeletal muscle. This study aimed to evaluate the effect of Ophiocephalus striatus extract on neutrophil count, soluble urokinase-type plasminogen activator (suPAR) level, diffusion capacity of lung for carbon monoxide (DLCO) and quality of life in stable COPD patients with muscle wasting.
Methods: Clinical pre and post quasi experimental study was conducted to 32 stable muscle-wasted COPD patients from Pulmonary Outpatient Clinic Saiful Anwar Hospital Malang, determined by The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016, Bioelectrical impedance analysis (BIA) dengan fat-free mass (FFM) <14.6 kg/m and Body Mass Index (BMI) <18.5 kg/m2, measurements of suPAR levels by enzyme-linked immunosorbent assay (ELISA), neutrophil count with blood analysis, DLCO with bodyplethysmography and CAT score as health-parameters COPD quality of life were performed before and after intervention of 3000 mg Ophiocephalus striatus extract for 12 weeks.
Results: There were significant decreased of CAT score (18.34±8.031 to 10.81±7.66, p=0.000), unsignificant decreased of suPAR (3.93±2.04 pg/mL to 3.77±1.67 pg/mL, p=0.67), unsignificant decreased of neutrophil (61.74±11.54% to 60.86±10.46%, p=0.619), unsignificant increased of DLCO (53.73±24,56% to 56.06±25,93% p = 0.369). There were weak negative correlations between suPAR to CAT score (r=0.44; p=0.813) and DLCO (r=-0.170; p=0.352), weak positive correlation between suPAR to neutrophil (r=0.167; p=0.370).
Conclusion: Twelve weeks supplementation of Ophiocephalus striatus extract in stable COPD patients with muscle wasting unsignificantly decrease suPAR and neutrophil levels and increase DLCO, but significant on CAT scores. No correlation between changes in suPAR, neutrofil, DLCO to CAT scores. (J Respir Indo 2019; 39(2))

Keywords


Ophiocephalus striatus extract, COPD, muscle wasting, suPAR, Neutrophil

References


Debigare R, Cote CH, Maltais F. Peripheral muscle wasting in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001; 164:1712-17.

Wüst RC, Degens H. Factors contributing to muscle wasting and dysfunction in COPD Patients. Int J Chron Obstruct Pulmo Dis. 2007; 2(3): 289¬300.

Schols AMJW, Broekhuizen R, Weling-Scheepers CA. Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr. 2005; 82(1):53-9.

Vogiatzis I, Terzis G, Nanas S, Stratakos G, Simoes DC, Gerogiadou O, et al. Skeletal muscle adaption to interval training in patients with advanced COPD. Chest. 2005;128(6):3838¬45

Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systemic review and a meta analysis. Thorax. 2004;59(7):574-80.

Langen RC, Schols AM, Kelders MC, van der Velden JL, Wouters EF, Janssen-Heininger YM. Muscle wasting and impaired muscle regeneration in a Murine model of Chronic Pulmonary Inflammation. Am J Respir Cell Mol Biol. 2006;35(6):689-96.

Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009;33(5):1165¬85.

Barnes PJ. Nutritional effects in COPD. Clinics in chest medicine: Chronic obstructive pulmonary disease. National Heart and Lung Institute, London. 2014; 118(11): 3546-56.

Xie J, Yang X, Shi J. A new inflammation marker of chronic obstructive pulmonary disease-adi- ponectin. World J Emerg Med. 2010; 1(3): 190¬5

Vanaudenaerde BM, Verleden SE, Vos R, De Vleeschauwer SI, Willems-Widyastuti A, Geenens R, et al. Innate and adaptive interleukin-17 producing lymphocytes in chronic inflammatory lung disorders. Am J Respir Crit Care Med. 2011; 183(8); 977¬86.

Rachel and Booker. Vital Lung Function: Your Essential References on Lung Function Testing. London, GBR. Class Publishing. 2007: 75¬84.

Munfatahatin N. Pengaruh pemberian ekstrak ikan gabus terhadap kenaikan berat badan pasien rawat jalan penyakit paru obstruktif kronik (PPOK) di Rumah Sakit Paru Jember (Penelitian eksperimental). [Skripsi]. Jember: Bagian Farmasi Komunitas Fakultas Farmasi Universitas Jember; 2010.

Mustafa A, Widodo MA, Kristianto Y. Albumin and zinc content of snakehead fish (Channa striata) extract and its role in health. International Journal of Science and Technology. 2012;1(2): 1-8.

Yang YC, Zhang N, Van Crombruggen K, Hu GH, Hong SL, Bachert C. Transforming growth factor beta 1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy. 2012; 67: 1193-202.

Draper E, Reynolds CM, Canavan M, Mills KH, Loscher CE, Roche HM. Omega¬3 fatty acids attenuate dendritic cell function via NF¬κB independent of PPARγ. J Nutr Biochem. 2011;22(8):784-90.

Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. National Institutes of Health. National Heart, Lung and Blood Institute.2016: 1-17.

Lim S, Lam DCL, Muttalif AR, Yunus F, Wongtim S, Lan LTT, et al. Impact of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region: the EPIC Asia population-based survey. Asia Pac Fam Med. 2015;14(4):1-11.

Iriani V, Muktiati NS, Djajalaksana S, Renata R, Nugroho SA. Pengaruh pemberian ekstrak Ophiocephalus striatus terhadap kadar TNF-α dan TGF-β1 serta kapasitas difusi paru dan kualitas hidup pada pasien PPOK stabil yang mengalami Muscle wasting [Tesis]. Malang: Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Brawijaya; 2017.

British Lung Foundation. Chronic Obstructive Pulmonary Disease Statistics. https://statistics.blf.org. uk /copd. 2017.

Kementrian Kesehatan Republik Indonesia. HTTS 2016: Suarakan kebenaran jangan bunuh dirimu dengan candu rokok. [Internet]. 2016. Available from: http://www.depkes.go.id/article/view/16060300002/htts-2016-suarakan-kebenaran-jangan-bunuh-dirimu-dengan-candu-rokok.html

Peabody JW Schau B, Lopez-Vidriero M, Vestbo J, Wade S, Iwbal A. COPD: A prevalence estimation model. Respirology. 2005;10(5):594–602

Tavenier, Elraheem SE, Shidfar F. Energy and protein intake and its relationship with pulmonary function in sepsis patients. Acta Medica Irania. 2017 ;48(6): 274-9.

Sugawara K, Takahashi H, Kasai C, Kiyokawa N, Watanabe T, Fujii S, et al. Effects of nutritional supplementation combined with low-intensity exercise ini malnourished patients with COPD. Respir Med. 2010; 104: 1883¬89.

Zaky DSE, Naiem M, Eid HA, Adawy ZR, Abd¬ Elraheem SE, Mohamed ZAZ. Circulating surfactant protein¬D as a biomarker of severity in stable chronic obstructive pulmonary diseases. Egyp J Chest Dis Tuberc. 2014; 63: 533-59

PT Royal Medicalink Pharmalab. Produk PT Royal Medicalink Pharmalab VipAlbumin. [cited March 15th 2016]. Available from: http://www. royalmedica.com/Produk/Vip1.html.

Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006;136(1):319S¬23S.

Du M, Shen QW, Zhu MJ, Fors SP. Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate activated protein kinase. J Anim Sci. 2007; 85(4):919–27.

Tomashow MA, Yip NH, Parikh M, Burkart KM, Lo Cascio CM, Shimbo D, et al. Randomization to omega¬3 polyunsaturated fatty acid supplementation and endothelial function in chronic obstructive pulmonary disease: The COD¬fish pilot randomized controlled trial. Am J Respir Crit Care Med. 2016;189:53-63.

Hsieh MJ, Yang TM, Tsai YH. Nutritional supplementation in patients with chronic obstructive pulmonary disease. J Formos Med Assoc. 2016;115(8):595-601.

Gea J, Agusti A, Roca J. Pathophysiolofy of muscle dysfunction in COPD. J Appl Physiol 2013;114(9):1222-34.

Jagoe RT, Engelen MP. Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease. Eur Respir J. 2003;46:52s¬63s.

Ferreira IM, Brooks D, White J, Goldstein R. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012:80-5.


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