Candida Glabrata Pneumonia in Post COVID-19 Patient: A Rare Case Report
DOI:
https://doi.org/10.36497/jri.v43i2.213Keywords:
candida, glabrata, pneumonia, post COVID-19Abstract
Background: One of the issues in post COVID-19 is secondary infection and fungal infection is one of the complications that must be detected at early stage to prevent. Early detection to prevent underdiagnosed and undertreatment. Candida glabrata, one of the pathogens in fungal infection is rare and can acts as infectious agent with immunocompromised patients.
Case: A 69-year-old man came to hospital with major complaints of cough and shortness of breath for five days. He was diagnosed COVID-19, After completed treatment the nasopharyngeal PCR swab show negative result for COVID-19. After being discharged, he did several chest X-ray examinations with progressively worsening cough. Chest CT-Scan revealed consolidations and cavity. Sputum culture was positive for Candida glabrata and negative for BTA. He received echinocandins as anti-fungal treatment, which inhibits enzymes that is necessary for fungi’s cell wall synthesis, shows clinical and radiological improvement.
Discussion: COVID-19 affect immune system which resulting higher risk for secondary infection. The use of broad-spectrum antibiotics, immune-suppression of the host, and use of medical devices are major risk factors for Candida infections. Meanwhile C. Albicans is still the most common cause of fungal pneumonia by Candida, we should consider C. glabrata as one of its pathogens.
Conclusion: COVID-19 affects many aspects in our life, even after we treat the main problem, some patients manifest symptoms later. Diagnosing fungal infection especially invasive candidiasis is quite challenging with higher mortality rate. Not only C. glabrata more uncommon than C. albicans, but also it was one of difficult to treat pathogens.
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References
Cennimo DJ. Coronavirus Disease 2019 (COVID-19)Transmission [Internet]. Medscape. 2021 [cited 2021 Feb 20]. Available from: https://emedicine.medscape.com/article/2500114-overview
Fernández-De-las-peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Cuadrado ML, Florencio LL. Defining post-COVID symptoms (Post-acute COVID, long COVID, persistent post-COVID): An integrative classification. Int J Environ Res Public Health. 2021;18(5):1–9.
Vijay S, Bansal N, Rao BK, Veeraraghavan B, Rodrigues C, Wattal C, et al. Secondary infections in hospitalized COVID-19 patients: Indian experience. Infect Drug Resist. 2021;14:1893–903.
Yazici O, Cortuk M, Casim H, Cetinkaya E, Mert A, Benli AR. Candida glabrata pneumonia in a patient with chronic obstructive pulmonary disease. Case Rep Infect Dis. 2016;2016:1–4.
Al-Hatmi AMS, Mohsin J, Al-Huraizi A, Khamis F. COVID-19 associated invasive candidiasis. J Infect. 2021;82(2):e45.
Aiyegbusi OL, Hughes SE, Turner G, Rivera SC, McMullan C, Chandan JS, et al. Symptoms, complications and management of long COVID: A review. J R Soc Med. 2021;114(9):428–42.
Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: A systematic review and meta-analysis. J Infect. 2020;81(2):266–75.
Song G, Liang G, Liu W. Fungal co-infections associated with global COVID-19 pandemic: A clinical and diagnostic perspective from China. Mycopathologia. 2020;185(4):599–606.
Mandanas RA. Fungal pneumonia [Internet]. Medscape. 2019 [cited 2021 Feb 20]. Available from: https://emedicine.medscape.com/article/300341-overview
Rolling T, Hohl TM, Zhai B. Minority report: The intestinal mycobiota in systemic infections. Curr Opin Microbiol. 2020;56:1–6.
Pemán J, Ruiz-Gaitán A, García-Vidal C, Salavert M, Ramírez P, Puchades F, et al. Fungal co-infection in COVID-19 patients: Should we be concerned? Rev Iberoam Micol. 2020;37(2):41–6.
Timmermans B, Peñas AD las, Castaño I, van Dijck P. Adhesins in candida glabrata. J Fungi (Basel). 2018;4(2):60.
Kaur H. Invasive candidiasis with cavitary lung lesion in a post-Covid-19 diabetic patient-A case report. Journal of Clinical and Medical Research. 2021;3(5):082.
Didbaridze T, Ratiani L, Labadze N, Maziashvili T. Prevalence and prognosis of candidiasis among Covid-19 patients: Data from ICU department. International Journal of Progressive Sciences and Technologies. 2021;26(1):36–9.
Sucher AJ, Chahine EB, Balcer HE. Echinocandins: The newest class of antifungals. Annals of Pharmacotherapy. 2009;43(10):1647–57.
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