Remdesivir in COVID-19: A Retrospective Analysis of Remdesivir Effectiveness and the Relation with Blood Type Variation
DOI:
https://doi.org/10.36497/jri.v43i1.392Keywords:
antiviral, blood type variations, covid-19, clinical outcome, remdesivirAbstract
identify the profile of the effectiveness of Remdesivir (RDV) therapy and its relationship to blood type variations in COVID-19 patients at Universitas Indonesia Hospital (RSUI).
Methods: Variations in blood types were examined for their influence on the effectiveness in Covid-19 infected patients with RDV as an antiviral treatment. Data for this study were acquired at RSUI using a retrospective cross-sectional method. The sample is infected patients with COVID-19 from January 2021 to December 2021 who received RDV therapy. The parameters of the effectiveness of the treatment was a reduction of minimally 2 points on the WHO Clinical Progression Scale after 14 days of Remdesivir administration.
Results: RDV effectiveness percentage shows 57.5% of patients experienced clinical improvement. The analysis results of the effect of blood type variations on clinical outcomes significantly affect the effectiveness of RDV therapy (OR: 1.705, 95% CI: 1.091–2.665; p = 0.019) but insignificant in terms of mortality status (OR: 0.654, 95% CI: 0.383–1.117; p = 0.120).
Conclusion: Blood type variations significantly affected the effectiveness of RDV therapy in infected COVID-19 patients.
Downloads
References
Chan JFW, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet. 2020;395(10223):514–23.
Susilo A, Rumende CM, Pitoyo CW, Santoso WD, Yulianti M, Herikurniawan H, et al. Coronavirus disease 2019: Tinjauan literatur terkini. Jurnal Penyakit Dalam Indonesia. 2020;7(1):45–67.
Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clin Chim Acta. 2020;508:254–66.
World Health Organization. Therapeutics and COVID-19: living guideline [Internet]. World Health Organization. 2022 [cited 2022 Oct 15]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2022.4
Burhan E, Dwi Susanto A, Isbaniah F, Aman Nasution S, Ginanjar E, Wicaksono Pitoyo C, et al. Pedoman tatalaksana COVID-19: Edisi 4. Indonesia: 4; 2022.
Malin JJ, Suárez I, Priesner V, Fätkenheuer G, Rybniker J. Remdesivir against COVID-19 and other viral diseases. Clin Microbiol Rev. 2020;34(1):1–21.
Gupte V, Hegde R, Sawant S, Kalathingal K, Jadhav S, Malabade R, et al. Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database. BMC Infect Dis. 2022;22(1):1–8.
Olender SA, Perez KK, Go AS, Balani B, Price-Haywood EG, Shah NS, et al. Remdesivir for severe coronavirus disease 2019 (COVID-19) versus a cohort receiving standard of care. Clin Infect Dis. 2021;73(11):E4166–74.
Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Relationship between the ABO blood group and the coronavirus disease 2019 (COVID-19) susceptibility. Clin Infect Dis. 2021;73(2):328–31.
Zietz M, Zucker J, Tatonetti NP. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun. 2020;11(1).
Du Y, Shi H, Yu J. Comparison in anesthetic effects of propofol among patients with different ABO blood groups. Medicine. 2017;96(20):e5616.
Magdalena, Sugiri YJ, Tantular R, Listyoko A. Clinical characteristics of COVID-19 patients in Dr. Saiful Anwar Hospital, Malang. Jurnal Respirologi Indonesia. 2021;41(1):7–14.
Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun. 2020;11(1):6317.
Henry BM, Lippi G. Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports. J Crit Care. 2020;58:27–8.
Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369.
Zhou Y, Yang Q, Chi J, Dong B, Lv W, Shen L, et al. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis. Int J Infect Dis. 2020;99:47–56.
Fathi M, Vakili K, Sayehmiri F, Mohamadkhani A, Hajiesmaeili M, Rezaei-Tavirani M, et al. The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study. PLoS One. 2021;16(2):e0246190.
Zhang J, Lu S, Wang X, Jia X, Li J, Lei H, et al. Do underlying cardiovascular diseases have any impact on hospitalised patients with COVID-19? Heart. 2020;106(15):1148–53.
Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology. 2020;17(1):11–30.
Yu P, Tan Z, Li Z, Xu Y, Zhang J, Xia P, et al. Obesity and clinical outcomes in COVID-19 patients without comorbidities, a post-hoc analysis from ORCHID trial. Front Endocrinol (Lausanne). 2022;13:936976.
Luo X, Jiaerken Y, Shen Z, Wang Q, Liu B, Zhou H, et al. Obese COVID‐19 patients show more severe pneumonia lesions on CT chest imaging. Diabetes Obes Metab. 2021;23(1):290–3.
Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H, et al. Obesity and mortality among patients diagnosed with COVID-19: Results from an integrated health care organization. Ann Intern Med. 2020;173(10):773–81.
Sahin S, Sezer H, Cicek E, Yaglz Ozogul Y, Yildirim M, Icli TB, et al. The role of obesity in predicting the clinical outcomes of COVID-19. Obes Facts. 2021;14(5):481–9.
Shibeeb S, Khan A. ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review. Hematol Transfus Cell Ther. 2022;44(1):70–5.
Göker H, Aladağ-Karakulak E, Demiroğlu H, Ayaz CM, Büyükaşik Y, İnkaya AC, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020;50(4):679–83.
Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220–3.
Downloads
Additional Files
Published
Issue
Section
License
- The authors own the copyright of published articles. Nevertheless, Jurnal Respirologi Indonesia has the first-to-publish license for the publication material.
- Jurnal Respirologi Indonesia has the right to archive, change the format and republish published articles by presenting the authors’ names.
- Articles are published electronically for open access and online for educational, research, and archiving purposes. Jurnal Respirologi Indonesia is not responsible for any copyright issues that might emerge from using any article except for the previous three purposes.
