The Effect of Opiocephalus striatus Extract on Leptin, Adiponectin and COPD Assessment Test Scores on Stable COPD Patients Experiencing Muscle Wasting
Abstract
imbalance of protein synthesis and degradation, where it is thought to be a consequence of chronic inflammation. One of the factor that affect
muscle wasting is nutritional factor. The purpose of this study is to prove that nutrition therapy can improve inflammation (measured by levels
of leptin, adiponectin) further improve muscle wasting and improve the quality of life of patients COPD with muscle wasting.
Method: The clinical study design is pre and post auto control quasi experimental in stable COPD patients with comorbid muscle wasting.
The experiment was conducted in Pulmonary Outpatient Clinic Dr. Saiful Anwar Hospital and Physiology Laboratory of Medical Faculty
Brawijaya University. Chronic obstructive pulmonary disease was diagnosed based on 2014 GOLD criteria. Muscle wasting was diagnosed
through examination of the BIA. Levels of leptin and adiponectin was measured using ELISA method, and quality of life was assessed
using CAT score. We measured BIA, Leptin, Adiponectin and CAT in 32 COPD patients with muscle wasting, before and after 12 weeks
supplementation of Opiocephalus striatus extract 3x1000mg/day.
Results: There were significant increased of BMI (p = 0.046), no significant increase of FFMI (p = 0506), a significant decrease in leptin
levels (p = 0.000) and a significant increase in adiponectin levels (p = 0.048) and improvement of quality of life (score CAT) (p = 0.000) ) after
administration of opiocephalus striatus extract for 12 weeks.
Conclusion: Suplementation of Opiocephalus striatus extract for 12 weeks can improve BMI, decrease levels of leptin and increase level
of adiponectin resulting in improvement of quality of life in stable COPD patients with muscle wasting.
Keywords
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Bruno A, Alessi M, Soresi S, Bonanno A, Riccobono L, Montalbono AM. Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers. J Inflamm Res. 2011;4:51-9.
Cingözler O, Özge C, Tamer L, Yıldırım H, Taşdelen B, Özgür ES. The relation of weight loss with hyperinflation, serum adiponectin, ghrelin and leptin levels in chronic obstructive pulmonary disease. Eurasian J Pulmonol. 2014;16:21-6.
Bianco A, Mazzarella G, Turchiarelli V, Nigro E, Corbi G, Scudiero O. Review: Adiponectin: An attractive marker for metabolic disorders in chronic obstructive pulmonary disease (COPD). Nutrients. 2013;5:4115-25.
Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. National Heart, Lung and Blood Institute.2015.p.9-16.
Yilmaz D, Capan N, Canbakan S, Besler HT. Dietary intake of patients with moderate to severe COPD in relation to fat free mass index: a cross sectional study. Nutr J. 2015;14:35.
Bolton CE, Evans M, Ionescu AA, Edwards SM, Morris RH, Dunseath G. Insulin resistance and inflammation – a further systemic complication of COPD. COPD Jun. 2007;4:121-6.
Agusti AGN, Sauleda J, Miralles C, Gomez C, Togores B, Sala E. Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166:485-9.
Toraldo DM, De Nuccio F, Scoditti E. Systemic inflammation in chronic obstructive pulmonary disease: may diet play a therapeutic role?. J Aller Ther. 2002;p.S2.
Sevenoaks M,Stockley R.A. Chronic obstructive pulmonary disease, inflammation and co-morbidity – a common inflammatory phenotype?. Respir Res. 2002;7:70.
Vanfleteren L, Spruit MA, Franssen F, Groenen M, Wouters EFM. Objectified co-morbidities in patients with COPD: the CIROCO study. [Internet]. 2012. [Cited 2015 Juli 15]. Available from: www.thoracic.org/about/newsroom/.../2012/vanfleteren%20final.pdf.
Munfatahatin N. Pengaruh pemberian ekstrak ikan gabus terhadap kenaikan berat badan pasien rawat jalan penyakit paru obstruktif kronik (PPOK) di Rumah Sakit Paru Jember (Penelitian Eksperimental). [Internet]. 2010 [Cited 2014 Oktober 20]. Available from: http://hdl.handle.net/123456789/15343.
Raizada N, Daga MK, Kumar N, Mathur S. Nutritional intervention in stable COPD patients and its effect on anthropometry, pulmonary function, and health-related quality of life (HRQL). JIACM.2014;15:100-5.
Sugawara K, Takahashi H, Kasai C, Kiyokawa N, Watanabe T, Fuji S. Effect of nutritional supplementation combined with low-intensity exercise in malnourished patient with COPD. Respir Med. 2010;104:1883-9.
Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008;294:1035-42.
Nigro E, Scudiero O, Sarnataro D, Mazzarella G, Sofia M, Bianco A. Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1β toxicity trough AdipoR1. Int J Biochem Cell Biol. 2013;45:1145-53.
Miller M, Cho JY, Pham A, Ramsdell J, Brioide DH. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J immunol. 2009;182:684-91.
Ghobadi H, Ahari S, Kameli A, Lari SM. The relationship between COPD assessment test (CAT) scores and severity of airflow obstruction in stable COPD patients. Tannafos. 2012;11:22-6.
Manihuruk D, Pandia P, Tarigan A, Eyanoer PC. Nilai COPD Assesment Test dan Modified Medical Research Council Dyspneu Scale dengan derajat Obstruksi dan Eksaserbasi Penyakit Paru Obstruksi Kronik. J Respir Indo.2015;35:218-22.
DOI: https://doi.org/10.36497/jri.v38i3.5
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