Email the author Increased Serum KL-6/MUC1 Level, Neutrophils and Lymphocytes Sputum in Malang Splendid Bird Market Workers
Abstract
Methods: This was an observational analytic cross-sectional study on 35 subjects, which examined and analyzed the characteristics of workers, percentage count of neutrophils, lymphocytes in induced sputum and KL-6/MUC1 serum levels using ELISA sandwich.
Results: Mean KL-6/MUC1 serum levels in the bird market workers increased (1152.67+583.92 U/ml) from normal levels (105.3-401.2 U/ml). There was a significant positive correlation between the length of exposure and KL-6/MUC1 serum levels (r=0.624; P<0.001). There were an increased in the mean percentage of sputum neutrophils and lymphocytes (90.71+4% and 9.17+4.42% respectively) compared to normal subjects (50.3+23.5% and 2.6+5.2%).
Conclusions: Increase percentage count of neutrophils and lymphocytes in sputum and KL-6/MUC1 serum levels indicated the presence of a chronic airway inflammation process, suspected increase in alveolar wall permeability, damage and regeneration of AEC type II due to inhalation exposure in bird market environment. (J Respir Indo. 2020; 40(2): 75-81)
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DOI: https://doi.org/10.36497/jri.v40i2.103
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