Asthma in Pregnancy: Mechanism and Clinical Implication

Triya Damayanti, Sri Pudyastuti

Abstract


Asthma in pregnancy can influence clinical status of an asthma patient. Study showed that one third of asthma patients were worsening, one third stable and one third improving. During pregnancy, lung function, ventilation pattern and gas diffusion are influenced by biochemistry (hormonal) and mechanic. Mechanism in pregnancy with asthma including hypoxia, inflammation, corticosteroids therapy, history of exacerbation, smoking mother and changes in placenta function. Hormonal status during pregnancy is different with non-pregnancy woman which hormonal level changes through the pregnancy time. Those changes can influence lung function in pregnancy. Treatment of asthma in pregnancy is giving optimal asthma therapy, therefore it can improve asthma control, also the quality of life of a mother and her fetus during pregnancy.

Keywords


pregnancy, asthma, hormonal, lung function

References


Murphy VE, Gibson PG, Smith R, Cliton VL. Asthma during pregnancy: mechanism and treatment implications. Eur Respir Rev. 2005;25:731-50.

Gaga M, Zervas E. Breathing for two: pregnancy, asthma and respiratory failure. Eur Respir Rev. 2014;23:5-7.

Murphy VE. Managing asthma in pregnancy. Breathe. 2015;11:258-67.

Murphy VE, Schatz. Asthma in pregnancy: a hit for two. Eur Respir Rev 2014; 23: 64-8.

Maselli DJ, Adams SG, Peters JI, Levine SM. Management of asthma during pregnancy. Ther Adv Respir Dis. 2013;7:87-100.

Namazy JA, Schatz M. Management of asthma during pregnancy: optimizing outcomes and minimizing risk. Semin Respir Crit Care Med. 2018;39:29-35.

Mangunnegoro H, Widjaja A, Sutoyo DK, Yunus F, Padjnaparamita, Suryanto E, et al. Asma:Pedoman diagnosis dan penatalaksanaan di Indonesia. Perhimpunan Dokter Paru Indonesia. Balai Penerbit FKUI. Jakarta.2004.

Sutoyo DK, Setyanto DB, Rengganis I, Yunus F, Sundaru H. Pedoman tatalaksana asma. Dewan Asma Indonesia. Jakarta.2011.

LoMauro A, Aliverti A. Respiratory physiology of pregnancy. Breathe. 2015;11:297-301.

Shedd GC, Hays CN. The pregnant patient with asthma: Assessment and management. The Journal for Nurse Practitioners. 2016;12:1-6.

Causevic M, Mohaupt M. 11B-Hydroxysteroid dehydrogenase type 2 in pregnancy and preeclampsia. Molecular Aspects of Medicine. 2007;28:220-6.

Haggerty CL, Ness RB, Kelsey S, Waterer GW. The impact of estrogen and progesterone on asthma. Ann Allergy Asthma Immunol. 2003;90:284-91.

Arora VK, Chachra V. Asthma in Pregnant Women. Indian J Allergy Asthma Immunol. 2011;25:115-23.

R. Hariadi. Ilmu Kedokteran Fetomaternal. Najoan Nan Warouw. Asma Bronkiale Dalam Kehamilan. Himpunan Kedokteran Fetomaternal. Surabaya. 2004: p. 549-58.

Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Pulmonary disorders: Asthma. In: Cunningham FG, editors. Williams Obstetrics. 24th ed. New York: McGraw-Hill Education;2014.p.6059-73.

Perhimpunan Dokter Paru Indonesia. Pedoman diagnosis dan penatalaksanaan asma di Indonesia. Jakarta: PDPI; 2019.

Global Initiative for Asthma. Global strategy for asthma management and prevention (Updated 2019) [cited 2020 Mar 27]. Available from: https://ginasthma.org/GINA-2019-main-report-June-2019-wms/.

Busse W, Clouter M, Dombrowski M, Nelson HS, Reed M, Schatz M, et al. Managing asthma during pregnancy: Recommendations for pharmacologic treatment. Update 2004. National asthma education and prevention program 2004.

British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 2014;69:i1-i192.




DOI: https://doi.org/10.36497/jri.v40i4.125

Refbacks

  • There are currently no refbacks.





Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845
Email: editor@jurnalrespirologi.org


An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International License

Statcounter