Premedication with Alprazolam for Bronchoscopy: Effect on Anxiety, Coughing, Breathlessness, and Pain Control

Yanny Octavia Sally Ride, Yusup Subagio Sutanto, Debree Septiawan


Background: Anxiolytic premedication can reduce anxiety, improving procedural tolerance, and reduce postbronchoscopic complications. There was ongoing debate about the safety of bronchoscopist-administered sedation. Alprazolam as a surgical premedication can reduce anxiety. Alprazolam can be used as an adjuvant analgesic, reduce anxiety-related breathlessness, and reduce coughing as adjuvant antitussive. The study aimed to evaluate the effectiveness of alprazolam in patients undergoing bronchoscopy.
Methods: A clinical study with quasi-experimental design , using consecutive sampling was performed in patient’s with lung tumor undergoing bronchoscopy in Dr. Moewardi Hospital from February to March 2019. The study subjects were divided in to given alprazolam and nonalprazolam(control groups). Scores of HADS, pain VAS, modified Borg, and cough VAS were measured in baseline, before, and after bronchoscopy.
Results: Thirty two subjects were involved in this study. The intervention groups showed decreased HADS pre- and postbronchoscopy (6.56+2.83 and 6.88 +2.63), pain VAS scores (15.00+10.95 and 9.69+11.61), cough VAS score (11.56+8.89 and 27.19+17.89), and these were different significantly compared to control group (p<0.05). We found decreased mean of modified Borg in the study group though they were not significant compared to those of in control group.
Conclusion: Alprazolam controlled anxiety, coughing, and pain in patients undergoing bronchoscopy. Alprazolam minimized breathlessness after bronchoscopy. (J Respir Indo. 2019; 39(4):)


alprazolam, bronchoscopy, lung tumor, HADS, pain VAS, modified Borg, cough VAS


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Jurnal Respirologi Indonesia
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