The Relationship Between Bacterial Pattern with Degree of Airflow Limitation FEV1 in Acute Exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital

Rianti Tarigan, Amira P Tarigan, Dian Dwi Wahyuni, Putri C Eyanoer


Background: Respiratory tract infections are the leading cause of acute exacerbation of COPD (AECOPD). The aim of this study was to investigate the relationship between bacterial pattern and the degree of airflow limitation (FEV1) in patients with acute exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital, also the sensitive antibiotics according to the susceptibility test.
Methods: This was a cross sectional study of all patients admitted to Adam Malik and Pirngadi Hospital with AECOPD from September 2015 until September 2016. In all 45 subjects who fulfilled the inclusion criteria, the spirometry was examination undergone to evaluate the degree of severity of COPD according to GOLD 2017. In each sample sputum expectoration, the gram smear was made. Barttlet criteria was used to calculate the amount of epithelial cells and PMN. The sample was then grown on blood agar medium. Bacterial susceptibility test to antibiotics was conducted using VITEC 2 methods.
Results: From 45 patients, 30 patients (66,7%) had positive sputum cultures. The most frequently isolated pathogen was Streptococcus pneumonia (26,7%). The most sensitive antibiotic was Amikacin (100%). There were no correlation between the in degree of airflow limitation FEV1 and bacterial sputum culture result. There were no significant differences between gram positive or negative bacteria with the degree of airflow limitation.
Conclusion: The incidence of bacterial infection based on positive sputum culture in AECOPD was about 66,7% Streptococcus pneumonia was the most common pathogen and Amikacin was the most sensitive antibiotic. There were no significant correlation between the degree of airflow limitation FEV1 with the positive or negative sputum culture and also with the result of gram staining. (J Respir Indo. 2019; 39(3):204-9)


Bacterial infection, sputum culture, acute exacerbation of COPD

Full Text:



Global Initiative for Chronic Obstructive Lung Disease. The Global strategy for the diagnosis, management and prevention of chronic lung disease. Update 2017. Capetown: Global Initiative for Chronic Obstructive Lung Disease Inc; 2017. p.???

Patel AK, Luhadia AS, Luhadia SK. Sputum bacteriology and antibiotic sensitivity pattern of patients having acute exacerbation of COPD in India: a preliminary study. J Pulm Respir Med. 2014;5:1.

Graham D. Definition, epidemiology and risk factors. British Med J. 2006;332:1442-4.

Perhimpunan Dokter Paru Indonesia. Penyakit Paru Obstruktif Kronik (PPOK). Pedoman praktis diagnosis dan penatalaksanaan di Indonesia. Jakarta: Balai Penerbit FKUI;2010.p3-9.

Departemen Kesehatan Republik Indonesia: Rokok jadi penyebab 22,6 persen kematian di Indonesia, {online} 2002[cited 2011 desember 20]. Available from: URL:

Miravitlles M, Espinosa C, Femandes LE. Relationship between bacterial flora-insputum and functional impairment in patients with acute exacerbations of COPD. Chest 1999;116:40-6.

Usyinara, Yunus F, Soepandi PZ. Pola dan sensitivitas kuman PPOK eksaserbasi akut pada sputum dicuci dan tidak dicuci sebelum dan sesudah pemberian erdostein dan antibiotik levofloksasin. [Tesis] Pulmonologi FKUI. Jakarta, 2006.

Eller J. Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. Chest. 1999;115(5):1481.

Groenewegen KHA, Emie LF. Wouters MA. Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study. Resp Medicine. 2003;7:770-7.

Hurst RJ, Vestbo J, Anzueto A. Susceptibility to exacerbations in chronic obstructive pulmonary diseases. N Eng J Med. 2010;363:1128-38.



  • There are currently no refbacks.

Copyright (c) 2019 Jurnal Respirologi Indonesia


SINTA Garuda Indonesian Scientific Journal Database (ISJD) Indonesia One Search (IOS) Crossref

ROAD-ISSN Dimensions Google Scholar 


Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845

An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International License