Factors that Affected the Mortality Rate of Chronic Obstructive Pulmonary Disease Patients with Respiratory Failure

Authors

  • Putri Nahrisyah Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan https://orcid.org/0009-0000-2314-8583
  • Fajrinur Syarani Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Amira P Tarigan Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Taufik Ashar Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan

DOI:

https://doi.org/10.36497/jri.v45i1.805

Keywords:

COPD, inhaler therapy, length of stay, mortality, type II respiratory failure

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a significant health issue with high morbidity and mortality rates. However, risk factors for COPD, particularly in cases with type II respiratory failure, are not fully understood. This study analyzes factors influencing the mortality rate of COPD patients with type II respiratory failure.

Methods: This observational study used a cross-sectional design, analyzing medical records of COPD patients with type II respiratory failure treated at H. Adam Malik General Hospital, Medan, from November 2021 to September 2022. A total of 42 patients met the inclusion criteria. Data analysis included descriptive statistics and inferential tests using the Chi-Square test and multiple logistic regression to identify the most dominant factors.

Results: Among the 42 patients, the mortality rate was 50%. Variables such as gender, age, number of comorbidities, smoking habits, and history of exacerbations were not significantly associated with mortality. Patients who did not regularly use inhalers had a 19-fold higher mortality risk than those who did (P=0.004; OR=19.79; 95% CI=2.67-146.99). Length of stay was inversely associated with mortality, with each additional day reducing the risk by 0.77 times (P=0.011; OR=0.77; 95% CI=0.63-0.94).

Conclusion: Routine inhaler use and length of stay are significant factors influencing the mortality rate in COPD patients with type II respiratory failure.

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Author Biographies

  • Putri Nahrisyah, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
    Department of Pulmonology and Respiratory Medicine
  • Fajrinur Syarani, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
    Department of Pulmonology and Respiratory Medicine
  • Amira P Tarigan, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
    Department of Pulmonology and Respiratory Medicine
  • Taufik Ashar, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan
    Department of Pulmonology and Respiratory Medicine

References

1. Miravitlles M, Vogelmeier C, Roche N, Halpin D, Cardoso J, Chuchalin AG, et al. A review of national guidelines for management of COPD in Europe. European Respiratory Journal. 2016;47(2):625–37.

2. Tamondong-Lachica DR, Skolnik N, Hurst JR, Marchetti N, Rabe APJ, de Oca MM, et al. GOLD 2023 Update: Implications for clinical practice. International Journal of COPD. 2023;18:745–54.

3. Mirza S, Clay RD, Koslow MA, Scanlon PD. COPD guidelines: A review of the 2018 GOLD Report. Mayo Clin Proc. 2018;93(10):1488–502.

4. Billo NE, Banatvala N, Bovet P, El Sony A. Chronic respiratory diseases: Burden, epidemiology and priority interventions. In: Banatvala N, Bovet P, editors. Noncommunicable diseases: A compendium. 1st ed. Routledge; 2023. p. 118–24.

5. Carone M, Antoniu S, Baiardi P, Digilio VS, Jones PW, Bertolotti G. Predictors of mortality in patients with COPD and chronic respiratory failure: The quality-of-life evaluation and survival study (QuESS): A three-year study. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2016;13(2):130–8.

6. Anggraeni M, Russilawati, Ermayanti S. Faktor-faktor yang mempengaruhi kejadian gagal napas pada pasien PPOK eksaserbasi akut di RSUP Dr. M. Djamil Padang. Jurnal Ilmu Kesehatan Indonesia. 2020;1(1):1–6.

7. Park SC, Kim DW, Park EC, Shin CS, Rhee CK, Kang YA, et al. Mortality of patients with chronic obstructive pulmonary disease: A nationwide population-based cohort study. Korean Journal of Internal Medicine. 2019;34(6):1272–8.

8. Hedsund C, Ankjærgaard KL, Rasmussen DB, Schwaner SH, Andreassen HF, Hansen EF, et al. NIV for acute respiratory failure in COPD: High in-hospital mortality is determined by patient selection. Eur Clin Respir J. 2019;6(1):1571332.

9. Hong WC, Yin CH, Hsu CW, Chen JS, Chen YS. Characteristics and predictors of mortality in patients with severely exacerbated COPD with acute respiratory failure. Res Sq. 2022;2.

10. Mirabile VS, Shebl E, Sankari A, Burns B. Respiratory failure in adults. Treasure Island (FL): StatPearls Publishing; 2022.

11. Chen WL, Chen CM, Kung SC, Wang CM, Lai CC, Chao CM. The outcomes and prognostic factors of acute respiratory failure in the patients 90 years old and over. Oncotarget. 2018;9(6):7197–203.

12. Shi T, Feng L. Blood biomarkers associated with acute type II respiratory failure in COPD: A meta-analysis. Clinical Respiratory Journal. 2022;16(2):75–83.

13. Durão V, Grafino M, Pamplona P. Chronic respiratory failure in patients with chronic obstructive pulmonary disease under home noninvasive ventilation: Real-life study. Pulmonology. 2018;24(5):280–8.

14. Ho TW, Tsai YJ, Ruan SY, Huang CT, Lai F, Yu CJ. In-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: A nationwide population-based study. PLoS One. 2014;9(12):e114866.

15. Akbaş T, Güneş H. Characteristics and outcomes of patients with chronic obstructive pulmonary disease admitted to the intensive care unit due to acute hypercapnic respiratory failure. Acute and Critical Care. 2023;38(1):49–56.

16. Medical Directorate NHS England. Overview of potential to reduce lives lost from chronic obstructive pulmonary disease (COPD). NHS England. 2014.

17. de Moreira ATA, Pinto CR, Lemos ACM, Assunção-Costa L, Souza GS, Netto EM. Evidence of the association between adherence to treatment and mortality among patients with COPD monitored at a public disease management program in Brazil. Jornal Brasileiro de Pneumologia. 2022;48(1):e20210120.

18. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2023 report. 2023.

19. Solidoro P, Albera C, Ribolla F, Bellocchia M, Brussino L, Patrucco F. Triple therapy in COPD: Can we welcome the reduction in cardiovascular risk and mortality? Front Med (Lausanne). 2022;9:816843.

20. Humenberger M, Horner A, Labek A, Kaiser B, Frechinger R, Brock C, et al. Adherence to inhaled therapy and its impact on chronic obstructive pulmonary disease (COPD). BMC Pulm Med. 2018;18(1):163.

21. Vestbo J, Fabbri L, Papi A, Petruzzelli S, Scuri M, Guasconi A, et al. Inhaled corticosteroid containing combinations and mortality in COPD. European Respiratory Journal. 2018;52(6):1801230.

22. Vestbo J, Anderson JA, Calverley PMA, Celli B, Ferguson GT, Jenkins C, et al. Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax. 2009;64(11):939–43.

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Published

2025-02-04

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