The Comparison of TGF-β Levels in Post Pulmonary Tuberculosis Patients with and Without Smoking History in Haji Adam Malik General Hospital Medan

Shilvanna Litania, Amira P. Tarigan, Fajrinur Syarani


Backgrounds: Pulmonary tuberculosis (TB) and smoking related disease such chronic obstructive of lung disease (COPD) is a major health problem around the world, particularly in development country such as Indonesia. Chronic airway obstruction as impact of tuberculosis may results in the course of tuberculosis or after completed the treatment. Transforming growth factor beta (TGF-β) is a cytokines that contribute to fibro genesis in post tuberculosis treatment. The aim of this study was to compare the TGF-β in post tuberculosis patients with and without smoking history.
Methods: This is an analytic study conducted with cross sectional design, began from October 2016 up to February 2017 in RSUP Haji Adam Malik Medan. All subjects had been recovered, confirmed by clinical, radiology and bacteriology examination. Smoking history of subjects using Index Brinkman. The TGF-β measurement was conducted from vein blood sample processed with Enzyme Link Immunosorbent Assay (ELISA) by using TGF-β kit.
Results: This study included 26 smoker - post pulmonary TB patients and 25 non-smoker, consisted of 31 males and 20 females. The mean level of TGF-β of all samples was 6690.5 ± 4913.4 mg/ml. The average of TGF-β level in smoker was 6621.5 ± 4856,7 mg/ml. Meanwhile the average of TGF-β level in non-smoker was 6762.2 ± 5071 mg/ml. Statistical analysis using Mann Whitney test revealed that there was no significant difference of TGF-β level among smoker and non-smoker post pulmonary TB patients (p = 0.618).
Conclusions: there was no significant difference of TGF-β level among smoker and non-smoker post pulmonary TB patients.


TGF-β, pulmonary TB, smoker


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Jurnal Respirologi Indonesia
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