Risk Factors for Depression Associated with The Use of Cycloserine in MDR TB Patients at dr. Soebandi Hospital
DOI:
https://doi.org/10.36497/jri.v45i3.883Keywords:
risk of depression, resistant, tuberculosis, antibioticsAbstract
Background: The most common psychological disorder in cycloserine treatment is depression. The purpose of this study was to determine factors that can affect the level of depression due to the use of cycloserine in MDR TB patients at dr. Soebandi Regional Hospital.
Methods: Data was obtained from medical records and the Depression Anxiety Stress Scales (DASS 42) questionnaire from 89 MDR TB patients at RSUD dr. Soebandi Regional Hospital in 2022-2024. Data analysis was done using Lambda and Somers test, and then the multivariate analysis was continued using ordinal logistic regression.
Results: The bivariate test results showed that the variables that significantly influenced the level of depression were gender (p=0.011), education (p = 0.000), occupation (p = 0.037), BMI (p = 0.000), and comorbidities (p = 0.029). Multivariate tests showed that three variables had a significant effect (p-value <0.05) on the level of depression, namely gender (p = 0.047), occupation (p = 0.001), and comorbidities (p = 0.011). The top two dominant risk factors affecting the level of depression are occupation (OR = 17,12) and comorbidities (OR = 9,14).
Conclusion: Occupation and comorbidities are the risk factors that most influence the level of depression in MDR TB patients receiving cycloserineDownloads
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