High Levels of Leucocyte and Thrombocyte Increasing COVID-19 Mortality Rate in RSUP Dr. M. Djamil Padang
DOI:
https://doi.org/10.36497/jri.v43i1.239Keywords:
clinical severity, COVID-19, leucocyte, thrombocyteAbstract
Background: Different leukocytosis, leucopenia, thrombocytosis, thrombocytopenia, and clinical severity appear in COVID-19's cases. This study is aimed to identify the association between leucocyte, thrombocyte, and clinical severity in COVID-19's outcome.
Methods: A retrospective cohort study involving 121 patients with COVID-19 whom admitted from January to March 2021. Kruskal Wallis test was applied for analysis.
Results: The majority of participants were female (55.4%), aged between 18-49 years old (42.1%), and had comorbidities (81.8%). Most participants had a normal range of leucocyte (57.9%), thrombocyte (62.8%), and moderate clinical severity (67.8%). Subjects with full recovery were 79.3%, with sequelae such as weakness, and/or shortness of breath 3.3%, and deceased 17.4%. Leucocyte and thrombocyte had an association with COVID-19 outcome (P=0.045 and P=0.030 respectively). Clinical severity had no association with COVID-19 outcome (P=0.304).
Conclusion: Leucocyte and thrombocyte have an association with COVID-19 outcome. Clinical severity has no association with COVID-19 outcome.
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References
Subkhan M, Ambar N, Airlangga M. COVID-19 in General. In: Paramitasari A, editor. Seminar Online Updates on Covid-19: Multidiciplinary Perspective. Surabaya: UMSurabaya Publishing; 2021. p. 3–25.
Chen R, Sang L, Jiang M, Yang Z, Jia N, Fu W, et al. Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China. J Allergy Clin Immunol. 2020;146(1):89–100.
Vinod N. Identifying patterns in COVID-19: Morbidity, recovery and the aftermath. International Journal of Clinical Virology. 2020;4(1):056–64.
Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: pPospective observational cohort study. BMJ. 2020;369.
Surendra H, Elyazar IR, Djaafara BA, Ekawati LL, Saraswati K, Adrian V, et al. Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study. Lancet Reg Health West Pac. 2021;9:100108.
Gusti I, Mardewi A, Yustiani NT. Gambaran hasil laboratorium pasien COVID-19 di RSUD Bali Mandara: sebuah studi pendahuluan. Intisari Sains Medis. 2021;12(1):374–8.
Priya S, Selva Meena M, Sangumani J, Rathinam P, Brinda Priyadharshini C, Vijay Anand V. Factors influencing the outcome of COVID-19 patients admitted in a tertiary care hospital, Madurai.- a cross-sectional study. Clin Epidemiol Glob Health. 2021;10:100705.
Long L, Zeng X, Zhang X, Xiao W, Guo E, Zhan W, et al. Short-term outcomes of COVID-19 and risk factors for progression. Eur Respir J. 2020;55(5):2000990.
Mohamed MS, Moulin TC, Schiöth HB. Sex differences in COVID-19: The role of androgens in disease severity and progression. Endocrine. 2021;71(1):3–8.
Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130(5):2620–9.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497–506.
Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 2021;93(3):1449–58.
Adriadi Ghiffari R, Geografi Pembangunan D, Geografi F, Gadjah Mada Jl Kaliurang U, Utara S, Mlati K, et al. Dampak populasi dan mobilitas perkotaan terhadap penyebaran pandemi COVID-19 di Jakarta. Tunas Geografi. 2020 Jul 26;9(1):81–8.
Khedr EM, Daef E, Mohamed-Hussein A, Mostafa EF, Zein M, Hassany SM, et al. Impact of comorbidities on COVID-19 outcome. medRxiv. 2020.
Demeco A, Marotta N, Barletta M, Pino I, Marinaro C, Petraroli A, et al. Rehabilitation of patients post-COVID-19 infection: A literature review. J Int Med Res. 2020;48(8):300060520948382.
Huang G, Kovalic AJ, Graber CJ. Prognostic value of leukocytosis and lymphopenia for coronavirus disease severity. Emerg Infect Dis. 2020;26(8):1839–41.
Li Q, Xie Y, Cui Z, Tang S, Yuan B, Huang H, et al. Analysis of peripheral blood IL-6 and leukocyte characteristics in 364 COVID-19 patients of Wuhan. Front Immunol. 2020;11:559716.
Zhao K, Li R, Wu X, Zhao Y, Wang T, Zheng Z, et al. Clinical features in 52 patients with COVID-19 who have increased leukocyte count: A retrospective analysis. Eur J Clin Microbiol Infect Dis. 2020;39(12):2279–87.
Alamin AA, Yahia AIO. Hematological parameters predict disease severity and progression in patients with COVID-19: A review article. Clin Lab. 2021;67(1):9–13.
Li Q, Cao Y, Chen L, Wu D, Yu J, Wang H, et al. Hematological features of persons with COVID-19. Leukemia. 2020;34(8):2163–72.
Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020;506:145–8.
Lanini S, Montaldo C, Nicastri E, Vairo F, Agrati C, Petrosillo N, et al. COVID-19 disease-Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study. PLoS One. 2020;15(12).
Al-Shamsi HO, Alhazzani W, Alhuraiji A, Coomes EA, Chemaly RF, Almuhanna M, et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: An international collaborative Group. Oncologist. 2020 Jun 1;25(6):e936–45.
Yang X, Yang Q, Wang Y, Wu Y, Xu J, Yu Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469–72.
Chen J, Jiang Q, Xia X, Liu K, Yu Z, Tao W, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020;19(7):e13168.
Li J, He X, Yuan Yuan, Zhang W, Li X, Zhang Y, et al. Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Am J Infect Control. 2021;49(1):82–9.
Eastin C, Eastin T. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. J Emerg Med. 2020;58(4):710–4.
Nalbandian A, Sehgal K, Gupta A, Madhavan M v., McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nature Medicine 2021 27:4. 2021;27(4):601–15.
Ratna Hidayani W, Studi Kesehatan Masyarakat P, Respati Stik. Faktor-faktor risiko yang berhubungan dengan COVID 19: Literature review. Jurnal Untuk Masyarakat Sehat (JUKMAS). 2020;4(2):120–34.
Drew C, Adisasmita AC. Gejala dan komorbid yang memengaruhi mortalitas pasien positif COVID-19 di Jakarta Timur, Maret-September 2020. Tarumanagara Medical Journal. 2021;3(1):42–51.
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