Indonesian Society of Respirology (ISR) Consensus Statement on Lung Cancer Screening and Early Detection in Indonesia

Sita Andarini, Elisna Syahruddin, Nathaniel Aditya, Jamal Zaini, Ferry Dwi Kurniawan, Sabrina Ermayanti, Noni Novisari Soeroso, Sri Melati Munir, Andreas Infianto, Ana Rima, Ungky Agus Setyawan, Laksmi Wulandari, Haryati Haryati, Ida Ayu Jasminarti, Arif Santoso

Abstract


Lung cancer is the leading cause of mortality for all cancer globally and in Indonesia. In Indonesia, lung cancer contributes to 12.6% of death of all cancer, making it the number one cause of cancer death, and 8.6% of all cancer incidence in 2018, behind breast, cervical, and colorectal cancer. The total cases per year are expected to almost double from 30,023 in 2018 to 54,983 cases in 2040. Smoking is among the risk factors for lung cancer, after occupational/environmental risk factors, history of lung fibrosis, and family history of cancer. There was a tendency of younger smokers in Indonesia and increased lung cancer incidence and prevalence in the younger population. The median age of lung cancer in Indonesia was younger than in any country, probably due to the younger age of smoking, early onset of carcinogens, asbestos use, and environmental. Lung cancer screening is a voluntary measure to detect lung cancer in the earliest stage, to find cancer at curable disease before symptoms appear in high-risk individuals. Lung cancer early detection is strategies to find cancer earlier after symptoms appear (cough, hemoptysis, dyspnea, chest pain). Low-dose computerized tomography of the thorax (LDCT) screening has been known to reduce lung cancer mortality compared to a chest x-ray (CXR). This Indonesian Society of Respirology consensus statement was aimed to give recommendations on lung cancer screening and early diagnosis in Indonesia.


Keywords


early detection, LDCT, screening

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References


Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.

World Health Organization. WHO global report on trends in prevalence of tobacco smoking 2000-2025. 2nd ed. World Health Organization; 2018.

Rami-Porta R, Call S, Dooms C, Obiols C, Sánchez M, Travis WD, et al. Lung cancer staging: A concise update. Eur Respir J. 2018;51(5):1800190.

Woodard GA, Jones KD, Jablons DM. Lung cancer staging and prognosis. Cancer Treat Res. 2016;170:47–75.

Lim W, Ridge CA, Nicholson AG, Mirsadraee S. The 8th lung cancer TNM classification and clinical staging system: Review of the changes and clinical implications. Quant Imaging Med Surg. 2018;8(7):709–18.

Rami-Porta R, Bolejack V, Crowley J, Ball D, Kim J, Lyons G, et al. The IASLC lung cancer staging project: Proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol. 2015;10(7):990–1003.

Rami-Porta R, Asamura H, Travis WD, Rusch VW. Lung cancer - major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):138–55.

S M, D O, Y A, A C, E van B. The 7th lung cancer TNM classification and staging system: Review of the changes and implications. World J Radiol. 2012;4(4):128–34.

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.

Eberhardt WEE, Mitchell A, Crowley J, Kondo H, Kim YT, Turrisi A, et al. The IASLC lung cancer staging project: Proposals for the revision of the M descriptors in the forthcoming eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 2015;10(11):1515–22.

Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, et al. Screening for lung cancer: US preventive services task force recommendation statement. JAMA. 2021;325(10):962–70.

Alberg AJ, Brock M V., Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e1S-e29S.

American Cancer Society. Key statistics for lung cancer [Internet]. Vol. 72, American Canser Society. Wiley; 2022 [cited 2022 Mar 7]. Available from: https://www.cancer.org/cancer/lung-cancer/about/key-statistics.html

Ji G, Bao T, Li Z, Tang H, Liu D, Yang P, et al. Current lung cancer screening guidelines may miss high-risk population: A real-world study. BMC Cancer. 2021;21(1):50.

MacMahon H, Naidich DP, Goo JM, Lee KS, Leung ANC, Mayo JR, et al. Guidelines for management of incidental pulmonary nodules detected on CT images: From the Fleischner Society 2017. Radiology. 2017;284(1):228–43.

Tindle HA, Stevenson Duncan M, Greevy RA, Vasan RS, Kundu S, Massion PP, et al. Lifetime smoking history and risk of lung cancer: Results from the Framingham heart study. J Natl Cancer Inst. 2018;110(11):1201–7.

Olsson AC, Vermeulen R, Schüz J, Kromhout H, Pesch B, Peters S, et al. Exposure–response analyses of asbestos and lung cancer subtypes in a pooled analysis of case–control studies. Epidemiology. 2017;28(2):288–99.

Keikha M, Esfahani BN. The relationship between tuberculosis and lung cancer. Adv Biomed Res. 2018;7(1):58.

Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, De Andrade M, Wiest JS, et al. A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet. 2004;75(3):460–74.

Wood DE, Kazerooni EA, Aberle D, Berman A, Brown LM, Eapen GA, et al. NCCN Guidelines® insights: Lung cancer screening, version 1.2022. J Natl Compr Canc Netw. 2022;20(7):754–64.

Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner society: Glossary of terms for thoracic imaging. Radiology. 2008;246(3):697–722.

Marshall HM, Bowman R V., Yang IA, Fong KM, Berg CD. Screening for lung cancer with low-dose computed tomography: A review of current status. J Thorac Dis. 2013;5(Suppl 5):S524–39.

Centers for Disease Control and Prevention. TB diagnostic tool: Xpert MTB/RIF assay fact sheet [Internet]. Centers for Disease Control and Prevention. 2022 [cited 2022 Mar 7]. Available from:https://www.cdc.gov/tb/publications/factsheets/testing/xpert_mtb-rif.htm

Perhimpunan Dokter Paru Indonesia. Pedoman nasional pelayanan kedokteran: Kanker paru. Jakarta; 2022.

The National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. New England Journal of Medicine. 2011;365(5):395–409.

de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med. 2020;382(6):503–13.

Wood DE, Kazerooni EA, Baum SL, Eapen GA, Ettinger DS, Hou L, et al. Lung cancer screening, version 3.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2018;16(4):412–41.

Bradley SH, Shinkins B, Kennedy MPT. What is the balance of benefits and harms for lung cancer screening with low-dose computed tomography? J R Soc Med. 2021;114(4):164–70.

Horeweg N, Scholten ET, de Jong PA, van der Aalst CM, Weenink C, Lammers JWJ, et al. Detection of lung cancer through low-dose CT screening (NELSON): A prespecified analysis of screening test performance and interval cancers. Lancet Oncol. 2014;15(12):1342–50.

Aggestrup LM, Hestbech MS, Siersma V, Pedersen JH, Brodersen J. Psychosocial consequences of allocation to lung cancer screening: A randomised controlled trial. BMJ Open. 2012;2(2):e000663.

Rasmussen JF, Siersma V, Pedersen JH, Brodersen J. Psychosocial consequences in the Danish randomised controlled lung cancer screening trial (DLCST). Lung Cancer. 2015;87(1):65–72.

Brain K, Lifford KJ, Carter B, Burke O, McRonald F, Devaraj A, et al. Long-term psychosocial outcomes of low-dose CT screening: Results of the UK Lung Cancer Screening randomised controlled trial. Thorax. 2016;71(11):996–1005.

Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW, et al. Benefits and harms of CT screening for lung cancer: A systematic review. JAMA. 2012;307(22):2418–29.

Rampinelli C, De Marco P, Origgi D, Maisonneuve P, Casiraghi M, Veronesi G, et al. Exposure to low dose computed tomography for lung cancer screening and risk of cancer: Secondary analysis of trial data and risk-benefit analysis. BMJ. 2017;356:j347.

Knight SB, Crosbie PA, Balata H, Chudziak J, Hussell T, Dive C. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9):170070.

Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004;64(11):3753–6.

Liu ZL, Wang H, Liu J, Wang ZX. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem. 2013;372(1–2):35–45.

Westhoff M, Litterst P, Freitag L, Urfer W, Bader S, Baumbach JI. Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: Results of a pilot study. Thorax. 2009;64(9):744–8.




DOI: https://doi.org/10.36497/jri.v43i2.455

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Copyright (c) 2023 Sita Andarini, Elisna Syahruddin, Nathaniel Aditya, Jamal Zaini, Ferry Dwi Kurniawan, Sabrina Ermayanti, Noni Novisari Soeroso, Sri Melati Munir, Andreas Infianto, Ana Rima, Ungky Agus Setyawan, Laksmi Wulandari, Haryati, Ida Ayu Jasminarti


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Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
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