Surfactant Protein A Serum Level in Cement Worker

Gunawan Gunawan, Sita Laksmi Andarini, Muhammad Ilyas, Arif Santoso, Ahmad Hudoyo, Irawaty Djaharudin, Harun Iskandar, Nur Ahmad Tabri

Abstract


Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia.

Methods: The design of this study was observational with cross-sectional. A sampling of cement-exposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017 – March 2018 and 17 healthy people as control. The serum level of SP-A was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area.

Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SP-A level in the study subject group or the exposed group was 6.02 ng/ml, and the mean SP-A level in the control group was 4.50 ng/ml. The difference in SP-A levels between the exposed and control groups was different but not significant, with value of P=0.084.

Conclusion: SP-A levels in the exposed and control groups were different but not statistically significant.


Keywords


Cement workers, Serum surfactant A, Silica exposure

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DOI: https://doi.org/10.36497/jri.v42i4.363

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