The Prevalence of Pulmonary Hypertension in Destroyed Lung Due to Post Pulmonary Tuberculosis and Its Relation to Exercise Capacity

Diana Septiyanti, Astari Pranindya Sari, Wahju Aniwidyaningsih, Budhi Antariksa, Bambang Budi Siswanto


Background: To improve patient’s quality of life, understanding destroyed lung (DL) is very important, however, it is very limited in information related to it as well as to the existency of pulmonary hypertension (PH) in destroyed lung. In this study, we investigated relationship between DL with PH status and the exercise capacity through 6 minutes walking test (6MWT).
Method: Cross-sectional analytic study involving 54 DL subjects. Subjects performed echocardiography to exclude cardiac abnormality and to determine whether they had PH. Subjects were then divided into two groups based on their PH status. They underwent 6MWT and their walking distance and peripheral oxygen saturation were measured. Student t-test was used for analyzing data. Furthermore, we determined correlation between walking distance and mean Pulmonary Artery Pressure (mPAP) value also peripheral oxygen saturation and mPAP.
Result: We calculated the mean of walking distance between the two groups. The mean from subjects with PH and without PH were 329.18 and 388.77 meter respectively (p=0.035). We found negative correlation between the mean of walking distance and subject’s mPAP using statistical analysis Pearson correlation test (r= -0,457, p = 0,001) while percentage of 6MWT by its prediction also had a negative correlation (r= -0,468, p= <0,001). Meanwhile, negative correlation also found between mean of peripheral oxygen saturation and their mPAP. There was no significant difference between peripheral oxygen saturation among PH non PH subjects.
Conclusion: Compared to subjects without PH, 6MWT value of destroyed lung with PH is lower and there is a correlation either walking distance and peripheral oxygen saturation with mPAP value. (J Respir Indo. 2018; 38: 227-31)


Destroyed lung; pulmonary hypertension; 6 minutes walking test

Full Text:



Eren Ş, Eren MN, Balci AE. Pneumonectomy in children for destroyed lung and the long-term consequences. J Thorac Cardiovasc Surg. 2003; 126:574-81

Galie N, Humbert M, Vachiery JL. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37:67-119

Sajkov D, Mupunga B, Bowden JJ, Petrovsky N. Pulmonary Hypertension in chronic lung diseases and/or hypoxia. Pulm Hypertens. 2013.p.21-45

Peacock A. Pulmonary hypertension. Eur Respir J. 2013;22:20-5

Gali N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2009;30:2493-537

Crapo RO, Casaburi R, Coates AL. ATS statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111-7

Sivaranjini S, Vanamail P, Eason J. Six Minute Walk Test in People with Tuberculosis Sequelae. Cardiopulmonary Physical Therapy Journal. 2010;21:4-10

McGavin CR, Artvinli M, Naoe H, McHardy CJ.Dyspnea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. BMJ. 1978;2:241-3

Seeger W, Adir Y, Barberà JA. Pulmonary hypertension in chronic lung diseases. JACC. 2013;26:1-5

Fowler RM, Gain KR, Gabbay E. Exercise intolerance in pulmonary arterial hypertension. Pulm Med. 2012;2012:1-7.

Saglam M, Vardar-Yagli N, Savci S. Functional capacity, physical activity, and quality of life in hypoxemic patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:423-8

Minai OA, Santacruz JF, Alster JM, Budev MM, McCarthy K. Impact of pulmonary hemodynamics on 6-min walk test in idiopathic pulmonary fibrosis. Respiratory Medicine. 2012;106:1613-21

Bourbonnais JM, Samavati L. Clinical predictor of pulmonary hypertension in. Sarcoidosis. Eur Respir. 2008;32:296-302



  • There are currently no refbacks.

Copyright (c) 2018 Jurnal Respirologi Indonesia


SINTA Garuda Indonesian Scientific Journal Database (ISJD) Indonesia One Search (IOS) Crossref

ROAD-ISSN Dimensions Google Scholar 


Jurnal Respirologi Indonesia
pISSN: 0853-7704 - eISSN: 2620-3162
Address: Jalan Cipinang Bunder No. 19, Cipinang, Pulogadung, Jakarta Timur, DKI Jakarta 13240, Indonesia
Phone: +62-21-2247-4845

An official publication by
the Indonesian Society of Respirology (ISR)

Creative Commons License
Creative Commons Attribution-NonCommercial 4.0 International License